Simple p2np synthesis I just thought I'd ask here to make sure. Introduction: P2NP, or phenyl-2-nitropropene, represents a chemical enigma that has captured the attention of researchers due to its distinct properties and applications. do you know what other solvents could be Abstract: This article explores P2NP, a compound integral in the synthesis of nitro-organic compounds. If precipitation doesn't commence at this point, water is poured in and the mixture put back in the fridge. Simple P2np Synthesis Sep 29, 2013 · A modified, small scale meth synthesis approach called the one-pot method, or shake-and-bake, or rolling the bottle involves the combination of all reactants in a two-liter soda bottle allowing the Mar 23, 2020 · 2. A 5 gram reaction is presented involving dissolving P2NP in isopropanol, making an aluminum amalgam, and adding it to a solution of glacial acetic acid and water. One such approach includes the hydrolysis of alpha-pheny … Jul 5, 2018 · I am going to try to prepare some P2NP from benzaldehyde and nitroethane following this procedure: The aldehyde (5g), 5 ml. Aug 27, 2021 · After adding the hydrocloric acid instead of yellow I got a bluish color what could this be attributed to? Dec 16, 2024 · SYNTHESIS OF 4-FLUORO-P2NP FROM NITROETHANE AND 4-FLUOROBENZALDEHYDE First of all I would like to thank G. Stirred and slightly heated for ca 4 hours. PHENYL 2-NITROPROPENE SYNTHESiS. I've been looking into a synthesis regarding alprazolam/flualprazolam, but I have a few questions. Mar 4, 2021 — I am going to try to prepare some P2NP from benzaldehyde and nitroethane following this procedure:. 060 mol benzaldehyde + . It is always recommended to consult with professionals or experts in the field for guidance and supervision when attempting any chemical synthesis. Apr 12, 2023 · I had assumed P2NP was one of the DEA List I chemicals, (ASS U ME), but I just read it's not. Aug 15, 2021 · this synthesis is two-stage. The substance is used in the synthesis of substances of the phenylalkylamines class, including methamphetamine and amphetamine as a starting material or intermediate. For those unaware P2NP is a compound easily made through the henry condensation. You can find details from Uncle fester book 8th edition meth manufacture, page 68. Water you need, because we are using 98% of acetic. Sep 15, 2022 · Synthesis ways Aside from the often reduction of (pseudo)ephedrine to methamphetamine, the most popular precursor to amphetamine and methamphetamine is phenyl-2-propanone. For example, you can get Phenyl-2-Nitropropene (P2NP) from Nitroethane, which is commonly found in RC vehicle fuel, but the problem is that it's not readily available in the US because it's a watched chem. Now to the question, if I keep all of the ingredients at the same scale but only increase the P2nP too 300g instead, what would the outcome be? Best regards Jun 24, 2023 · Hello Alcheringa Viewers, in this video I will be synthesising 1-phenyl-2-nitropropene from benzaldehyde. Apr 4, 2023 · This is gonna yield you pretty pure racemic d and l isomer amphetamine id imagine, I haven't watched the video in a while but I believe its reductive amiantion reducing p2np with NA BH4 USING the anhydride to reduce the nitropene etc etc, if you are still lost maybe a more simple compound would help, the mescaline from styrene helped me Hey guys I am trying to synthesis P2NP,I did find benzaldehyde but could not find nitroethane so I am going to synthesis it, however i still did not find one of the ingredient "sodium ethyl sulphate" so I am going to attempt to synthesis it today with sodium bisulphate,ethanol and sodium carbonate. : How much HCl will we need? On Erowid Forum, this P2P method of P2NP with NABH4, but in a small scale. Reactions: rampage Apr 3, 2023 · Adhere to all local laws, regulations, and safety guidelines pertaining to chemical handling, disposal, and the synthesis of specific substances. Apr 23, 2020 · Talking about the henry reaction in part 1. It starts with the aromatic benzene ring, a cornerstone of organic chemistry, and progresses through a series of carefully orchestrated steps involving nitration, reduction, and purification. There are several methods for purifying P2P from its impurities, including purification through the bisulfite derivative and simple steam distillation. Hunt, Thallium in organic synthesis. Reactions: rampage so i guess that most of you are sick of all the questions about p2np synthesis but i'm trying to perfect the ammonium acetate synth using a dean stark trap. They share a procedure for these synthesis. I pasted that relevant section. A simple reflux with anhydride can be performed with all of these over the course of 5-10 minutes, this method provided the best results especially with acetic anhydride and propionic anhydride. Introduction: P2NP, a precursor in nitro-organic synthesis Aug 11, 2021 · The P2NP oil layer will slowly (or sometimes quickly) start forming a crystalline layer. You are ready t o st art react ion alium inium am algam in t o acet ic acid wit h wat er m ix for about 3- 5 m inut es, while solut ion will be grey can st ir it. of P2NP, FC of Benzene w/ Chloroacetone, Hydrolysis of Ephedrine derivatives, Electrolysis of Benzyl Chloride and AA, Ni-med. 266 mol of nitroethane -> . Bisulfite Method. A mixture of 1-phenyl-2-nitropropene (P2NP) 1. the first stage is the reduction of the double bond in nitropropene with borohydride. Introduction: P2NP serves as a crucial intermediate in organic synthesis, facilitating the production of pharmaceuticals, agrochemicals, and fine chemicals. What I should also mention is that in order to shorten the process of administering P2NP, I place the flask in a large container full of ice, which I then heat over a hotplate. Aug 11, 2021 · Language Joined Apr 10, 2022 Messages 301 Reaction score 172 Points 43 Hell, I even posted about what alkylamine catalyst to use for the p2np synthesis on this same subreddit and literally got told I was simply making it more complicated than it really was. 1-Phenyl-2-Nitropropene (P2NP) is a chemical compound with the molecular formula C9H9NO2. Tetrahed. com/media/phenylacetone-p Benzyl Cyanide, PAA, FC of Benzene w/ 2-nitropropane, Red. C. i got a 30% yield, which would indicate a poor synthesis (i made a few mistakes as Feb 13, 2018 · Abstract The Leuckart–Wallach reductive amination reaction in clandestine amphetamine synthesis is the most popular, simple, rapid, and safe non-metal reduction route, in which its mechanism is not known with certainty. I've looked into the amphetamine synthesis. 5 g P2NP 2 g CuCl2 +-0. A. my biggest problem is that i couldnt find much information about the solubility of p2np in diffrent solvents. 150ml of saturated NaHCO3 water solution was prepared. 2: 265 (1908) Aug 15, 2021 · The first time 80g P2NP, the second time 200g P2NP and the last time 250g P2NP. 0 g) in nitroethane (20 mL) was heated to reflux for 5 h. In the end I didn't even receive A-Oil. McKillop and J. CuCl2 (30 g) in water (57,50 ml) was added at once the temperature of the mixture did not Aug 15, 2021 · Used was IPA/water in 2:1 ratio like in original synthesis (1200ml IPA / 600ml Water) 150g NaBH4, added in 2 portions, first portion 100g at the start mixed with ipa and water Then after all the p2np has been added (when adding p2np use cold water for cooling the vessel) Aug 28, 2023 · P2NP synthesis, or the synthesis of phenyl-2-nitropropene, is a chemical process used in the production of various substances, including pharmaceuticals and illicit drugs. But usually with stirring in 2-HEAA for 1 - 48 h, depending on substrates. . Ah, the sweet symphony of chemical synthesis! But what’s the hype around P2NP, you ask? Well, my friend, allow me to take you on a journey through its synthesis and potential applications. I followed every step from the So with all the talk of amphetamine synthesis recently (mostly just the alpha methyl cinnamaldehyde synthesis but whatever) I decided to optimize my personal favorite amphetamine synthesis, P2NP. 1-Phenyl-2-nitropropene (P2NP) is a precursor of amphetamine and will synthesized from benzonitrile. 36ml of lab grade benzaldehyde was poured in the solution with a syrenge and vigorously stirred. Try it in small quantities, starting with the correct amalgam. com/threads/p2p-synthesis-from-p2np. First, we make an aluminum amalgam. Chim. ANOTHED METHOD OF P2P SYNTHESIS. Add p2np in two stages and control the temperature of the amalgam. One organic molecule that is highly relevant to both scientific and industrial applications is 1-phenyl-2-nitropropene (P2NP). something like xylene would be great if it was possible but i doubt that the hgcl2 would be soluble in this. To embark on this journey, one must first understand the intricate chemistry behind P2NP synthesis. I apologize for being condescending; I barely know anything about you, and if I assumed something about you that isn’t true then I’m sorry and really wasn Amphetamine synthesis via NaBH4 reductive amination from P2NP. In general, the product should still be purified after synthesis. Apr 4, 2023 · This is gonna yield you pretty pure racemic d and l isomer amphetamine id imagine, I haven't watched the video in a while but I believe its reductive amiantion reducing p2np with NA BH4 USING the anhydride to reduce the nitropene etc etc, if you are still lost maybe a more simple compound would help, the mescaline from styrene helped me Mar 6, 2022 · Hello members. Tiffeneau, Transformation of magnesium derivatives of chlorohydrins. If it doesn't, scratching the wall with e. 5H2O 7. Aft er adit ion in t he 5- 10 m inut es will st art st orm y Feb 14, 2024 · Phenyl-2-nitropropene (P2NP) is a versatile organic compound with diverse synthetic applications, offering chemists a valuable tool for the preparation of various organic molecules. XX. Aug 11, 2021 · . Jun 1, 2018 · This route is a three step synthesis to P2P; an aldol condensation of benzaldehyde and methyl ethyl ketone (MEK), a Baeyer-Villiger reaction and a subsequent ester hydrolysis. 4 times more nitroethane than benzaldehyde hell of an excess for yield that's average at best. The most ubiquitous non-discriminating synthesis is the P2NP reduction, which could be accomplished with an aluminium amalgam. This system is fully automatic and you don't need to worry about overheating, and the temperature is consistent. Phenyl-2-Nitropropene à la Barium: 1 mol benzaldehyde, 1. Org. as well as solvent, for the synthesis of P2NP yet too, and besides an astonishing yield of 92% of P2NP while using only 1:1,1 mol aldehyde to nitroalkane, with still only around 15ml used instead of the advised 5 times eq. The resulting . Look carefully at the relevant topic. 2 mol nitroethane and 15 mL diluted aqueous methylamine in 150 mL alcohol. 60, 5275 (1970) M. Even the simple 1 pot synthesis with 30% ammonia solution sounds good to me. The synthesis of impurities detected in clandestinely manufactured Amphetamine Type Stimulants (ATS) has emerged as more desirable than simple "fingerprint" profiling. On cooling, after removal of the solvent, the residue was purified by column chromatography on silica gel 60 N (neutral Sep 2, 2021 · A solution of 1-phenyl-2-nitropropene 10 g in 100 ml of isopropyl alcohol and 50 ml of acetic acid is prepared before the synthesis start. They give 300ml HCl to achieve acidity, so in yours method in a big scale, how much HCl will we need? Aug 11, 2021 · The bucket with mixture is put into a freezer for 12 hours, 1-phenyl-2-nitropropene (P2NP) is crystallized. Aug 15, 2021 · Synthesis: 1. Our next thought was a selective cleavage of the dimethylformamide providing 4-(4-chlorophenyl)-1-(3,3-diphenylpropyl)-4-piperidinol, however this Dec 23, 2024 · Search titles only. For a more in-depth discussion of this synthesis, read Drone #342's Enolate Phenylacetone Synthesis FAQ 1. Chemists and researchers are exploring the compound's properties, investigating its potential in the development of new materials, pharmaceuticals, and even as a The Willstatter̈ lab completed the first synthesis of (−)-cocaine (122) in 1903 . 675 H2o NaOH (25% water solution) 16 ml Acetone (dry) 5-10 ml I first put ipa and h2o and mix for 2 minutes, then I add p2np, then I dissolve 0. the toluene serves to remove water from the reaction in a dean stark trap while the methanol is used to Aug 15, 2021 · Luckily this happened shortly before the addition of CuCl2. Aug 11, 2021 · Reaction scheme: Equipment and glassware: 10 L Flask; Retort stand and clamp for securing apparatus (optional); Reflux condenser; Funnel; Vacuum source; Laboratory scale (0. In all cases the P2P was synthesized by the reduction of P2NP by Fe powder with equal proportions of reagents in each run. We have been investigating the impurities formed when phenyl-2-propanone (P2P) 5, a key ATS precursor, is synthesised in three steps … Sep 2, 2021 · If you have followed this synthesis and drop sulfuric acid into your solution at the end, then amphetamine sulfate will precipitate there until you reach pH6, anything below that means loss in yield and further impurities. Point being, most recently I purchased powdered iron for the reduction from a new vendor which is cheaper but at first sight of a much worse quality than the essentially pure one which I've used before with much larger The full synthesis video is available on the official website:https://chemforum. For more exclusive content check out my website: bu In essence, P2NP synthesis represents the fusion of artistry and scientific rigor. the second stage is the reduction of the nitro group on a copper catalyst, borohydride is only a source of hydrogen for the copper catalyst, therefore, it is possible to change the reaction and carry out reduction in an acidic environment, the reducing agent can be changed. The document describes an easy method for synthesizing amphetamine from readily available chemicals like phenyl-2-nitroproene (P2NP) and mercuric chloride. Talking about the henry reaction in part 1…………In part 2 I talk about 3 examples or ways to do the henry reaction to make P2nP. After refluxing and treating with sodium hydroxide and dichloromethane P2NP can also be reduced to phenylacetone (P2P), the precursor in the synthesis of methamphetamine by a few methods. Apr 5, 2023 · After P2NP crystallized out you shall distill off 60% from the liquids left over, add 1 gr crystall P2NP into it, put in freezer and another 5-8% of P2NP will crystallize out from that (little darker, need to be re-crystallized 2x). Note that my experience excludes P2NP, but variously substituted nitrostyrenes, phenylnitropropenes and phenylnitrobutenes. Than add P2NP solut ion and st ir a lit t le bit . Also, an aluminium foil 12 g is cut into small pieces with a paper shredder for an aluminium amalgam preparation. ) concentrated 4 ml in toluene 5 ml and water 5 ml are stirred vigorously at 75 °C for 18 h in 50 ml flask with reflux condenser. of the nitroalkane, and 2g of ammonium acetate were added to 20 ml of gla They can be divided into 3 types: biosynthesis (using biomass), direct synthesis, and synthesis of racemic (the sum of l- and d-isomers) amphetamine followed by separation of optical isomers. NaBH4 (500gr) was added at once while stirring. In part 2 I talk about 3 examples or ways to do the henry reaction to make P2nP. It's fairly simple and is a one step reaction, the problem is sourcing the precursor and reagants. 225. This was my path: p2np 10g IPA/H2O (1:2) IPA 120ml/H2O 60ml (180ml) NaBH4 17. 10, 322-378 (1908). Bisulfite. 2 g 9. Aug 15, 2021 · Here is a simple blueprint of my setup, recommendation is to also connect the waterbath to a separate cooling container in the fridge that holds larger amount of water 25-30L. Aug 27, 2021 · Is this Synthesis suitable for Beginners? When mixing,cooled the 20 L Round bottom flask must be closed? In what step do we use Rotovap? Step 9. 8. 77,78 This was a landmark moment in organic synthesis, as it involved the formation of the tropinone core and set a new precedent for the complexity that chemical synthesis could reach. Got organish yellow oil after quenching with water. Aug 11, 2021 · 1. 9% purity Benzyl Methyl Ketone, also known as BMK Oil or BMK Powder. Here, the authors show a reductive amination Aug 11, 2021 · 1. This article provides an in-depth exploration of the synthesis methods, chemical properties, and diverse applications of P2NP, highlighting its role as a key intermediate in the production of various organic compounds. 5 g (0. 6 g, and hydrochloric acid (HCl 36% aq. The prevailing theory here is that the easiest route to phenethylamines from a nitrostyrene is zinc/HCl, however the temperature control can be very sensitive and the workup/basification to the freebase afterwards is a Aug 27, 2021 · Is this Synthesis suitable for Beginners? When mixing,cooled the 20 L Round bottom flask must be closed? In what step do we use Rotovap? Step 9. 031 M, 1 eq), m. With P2P , the Leuckart route (VI) and reductive amination are the most commonly used routes for the synthesis of MA [48,60]. Apr 5, 2017 · Amphetamine sulphate synthesis What we are need is: 5g P2NP 50ml Isopropanol 7,5-8,5g of Aliuminium foil (better to use thick foil) 50ml 98% acetic acid (can also use 70%, than don’t need water) 50g NaOH 1ml H2SO4 Firstly, you will make mix with acetic acid and water. Aug 15, 2021 · Luckily this happened shortly before the addition of CuCl2. MAYB May 26, 2023 · Hi, i just failed my first synthesis. Sep 30, 2023 · Ammonium Acetate Catalysis in Excess Nitroethane3 A solution of benzaldehyde (6. One in which phenyl-2-nitropropene is reduced to phenyl-2-nitropropane using sodium borohydride , followed by hydrolysis of the nitro group with hydrogen peroxide and potassium carbonate to produce phenylacetone (1-phenyl-2 Aug 11, 2021 · The bucket with mixture is put into a freezer for 12 hours, 1-phenyl-2-nitropropene (P2NP) is crystallized. It failed completely. 1-500 g is suitable) - optional; Measuring cylinders 1000 mL and 100 mL; Water bath; Glass rod and spatula; Filter May 28, 2022 · This is the detailed method. 65-66C NaBH4 - 8. Introduction to 1-Phenyl-2-Nitropropene. i can do 70g P2NP in a 2L flask which is much better that the Al/Hg method @ 10g. Solution IPA/H2O 2:1 (10,4L) was added to the reactor and stir at room temp. Patton and WillD for their support and chemical and methodological knowledge which helped me to obtain very good synthesis results with great success! Laboratory tools: 4-liter Sep 2, 2021 · my second concern is my p2np does not disolve in my IPA/acetic acid mixture given the 10g P2NP in 100 ml isopropyl and 50 ml glacial acetic acid. of the nitroalkane, and 2g of ammonium acetate were added to 20 ml of glacial acetic acid. g. info/threads/amphetamine-synthesis-from-p2np-via-al-hg-video. Simple p2np synthesis raffike (Hive Addict) 12-11- 02 . It is needed in order to clean the aluminum from the strong oxide layer that forms when interacting with air. The last one was the best of all, as I managed to stick exactly to the temperatures. This process involves the conversion of benzaldehyde to P2NP, which is then further modified to produce different compounds. The second step is particularly hazardous as it generates heat and needs to be carefully controlled to avoid explosions and fires breaking out at the production sites – particularly if the synthesis is being conducted on a large scale. Oct 26, 2024 · I tried synthesizing P2P from P2NP using tin chloride dihydrate. There is an astounding array of synthetic routes to this compound, both due to the relative simple structure of the compound, and also because of its popularity. If you want to buy p2np you. When using acetic acid as solvent, a dean stark trap doesn't make sense, but you could perhaps attach a bigger drying tube with baked MgSO4 or so. This article embarks on a journey to elucidate the nuances of P2NP synthesis through the cyclohexane route, exploring its chemical intricacies, synthetic methodologies, and practical applications. Sep 2, 2021 · The cooled and crystallized P2NP is easily added to 50ml of glacial acetic acid and heated to dissolve. Aug 15, 2021 · P2nP, 200g CuCl2, 20g + 40ml H2O NaoH 25%, 1,6l I learned that the scale was linear so these are the measurements I concluded. At its core, p2np synthesis is a testament to the ingenuity of organic chemistry. It is commonly known as P2NP and is widely used in the field of chemistry for various purposes, including pharmaceuticals and illicit drug synthesis. i need aprox 120-130 ml of IPA and propably 70 ml acetic acid to disolve th ep2np, otherwise i have yellow crytsals swirling around in my solution. The reaction mixture is brought over into a beaker and cooled in the fridge (4°C). 1953, 18 (1), 1–3. I added methylamine to the mixture and then added aluminum and hcl to reduce it to methamphetamine free Amphetamine Synthesis Approaches. P2NP (287gr) was added in small portions, so that the temperature of the mixture did not exceed 60 *С. 4g CuSO4. D. When dcm was added it formed a turbid pale yellow mixture of dcm and p2p. The beaker was covered with another beaker to limit the oxygen exposure and was left for 2-3 min for layers to separate. I followed the steps exactly as shown in the video for this synthesis except I wasn’t able to bring the temperature down to 0-5deg Celsius on the NaBH4 addition step. Nevertheless, chemist have to pay attention to safety and use PPE. I'd like to ask for your opinion (I don't speak English). Oct 18, 2021 · Synthesis of amphetamine from P2NP via Al/Hg. It is commonly known as P2NP and is widely used in the field of chemistry for various purposes, including pharmaceuticals and illicit drug For quite a long time, the clandestine synthesis of MA employs three major precursors, namely ephedrine, pseudoephedrine, and the 1-phenyl-2-propanone (P2P) [, , , , ]. - dissolved p2np in acetone / EtoH and brought solutions of sncl2/p2np-solvent together in 250ml RBF Mar 12, 2024 · P2NP, or phenyl-2-nitropropene, stands as a pivotal intermediate in the synthesis of various organic compounds, including pharmaceuticals and fragrances. The aldehyde 5g5 ml. To quote: The aldehyde (5g), 5 ml. Aug 15, 2021 · my calculation on the p2np nabh4 amphetamine method IPA 40-50 ml H2O 12,5 ml NaBH4 3. 1-Phenyl-2-propanone (P2P) is an internationally monitored precursor that has become increasingly difficult for illicit amphetamine producers to source, which means that alternative routes to its preparation have become increasingly important. Aug 15, 2021 · All in all this synthesis was fun, very simple and effective. This is everything you need for making P2NP, from left to right: Pipette-aparatus, several pipettes, dean&stark trap, PTFE greas, toluene, measuring cylinder 100ml, nitroethane, benzaldehyde, n-butylamine, above the brown flask a heating mantle and a 250ml RB-flask. The reaction is a nitroaldol reaction, and is a variant of a Knoevenagel condensation reaction, which is one of a broader class of reactions called Henry condensations, or simply Henry reactions. On cooling, after removal of the solvent, the residue was purified by column chromatography on silica gel 60 N (neutral Nov 5, 2024 · The synthesis of amphetamine from p2np al/hg is considered quite simple, but it has its own characteristics. Ann. My question now: Can the mixture of NabH4 and P2NP be separated in any way so that both can be returned to their original forms? so that it can be used again for another new synthesis. Manganese(III)ac Feb 10, 2024 · i just did this synthesis successfully ! (i was very astonished, that it works, like described!) i used 1,7g P2NP - created sncl2 sol. Each stage requires precision and careful control of reaction conditions. Apr 8, 2024 · In the clandestine world of organic chemistry, there exists a gem known as P2NP, short for Phenyl-2-Nitropropene. ( AMF AI/Hg) scaled down by 1/2 of everything ( compare to the :how-to-video, so 5grams of p2np) i think my amalgam was wrong, ( i've read the thread from gpatreon about amalgation) but is it normal that my p2np in IPA and water solution became mushy ? ( Aug 15, 2021 · 5 g of P2NP was ground in a mortar and slowly added to the RM, temperature didn't rise above 25 °C. Through a meticulous exploration, we aim to unravel its synthesis, molecular characteristics, and diverse chemical properties, shedding light on its role as a key intermediate in the creation of various valuable organic molecules. a glass rod will help. 3. Any advice for buying it, as in will it draw attention to me? Thanks! Aug 15, 2021 · i did synthesize a very small batch (my very first synthesis of amphetamine) with p2np that hadn't been potentially contaminated, and where everything else about this synthesis was the same as all of the other ones I did with the (most likely) contaminated p2np. 4 g) and ammonium acetate (1. Through collaboration and dedication, chemists wield their skills to craft molecules, unraveling the mysteries of molecular synthesis, and leaving an indelible mark on the canvas of chemical innovation. This article embarks on an in-depth exploration of P2NP, unraveling its molecular intricacies, synthesis methods, and its significance in various chemical processes. The yield is 65-75%. We now report on our investigations into the synthesis of P2P analogues from substituted benzaldehydes via the Baeyer-Villiger route. p. Oct 17, 2024 · To achieve the desired synthesis results, it is necessary to purify the initial P2P from impurities. 196/https://bb. Aug 15, 2021 · After I added the CuSO4*5H2O and then held the solution at 80c for 30 minutes, I added hydrochloric acid in the absence of acetic acid (that should be ok?) so the solution reached ph 2, and then I used simple distillation to distill off the IPA between the temps of 83C - 91C (although virtually nothign came over past about 87c), then cooled down the solution, filtered it, then added the May 14, 2023 · I want to manufacture amphetamine on an industrial scale from P2NP and I would like to know what is the best route. The product P2NP is filtered on a Buchner funnel (suction filtration procedure), washed be a small amount of cold IPA and dried on air (or in vacuum chamber, optional). The proposed synthesis is: Start with 2-amino-5-chlorobenzophenone 1 (for making alprazolam), and add chloroacetyl chloride 2. Remove the gray dirty water from the aluminum flakes and wash them twice with pure water Then add the P2NP solution into the aluminum flask (at this time there will be a large amount of reaction and the temperature will rise rapidly. This may be more suited to the beginner sub, but it's banned (I have performed organic syntheses before). P2NP synthesis/crystalization problem 1. Edit: thinking back, I also made P2NP and P2NB, but never reduced, lol. Unraveling the Mystery of P2NP Synthesis ipa is mostly used for the reduction of p2np with al/hg, but as i've just run out i was wondering what other solvents could be used. Amphetamine sulphate synthesis What we are need is: 5g P2NP 50ml Isopropanol 7,5-8,5g of Aliuminium foil (better to use thick foil) 50ml 98% acetic acid (can also use 70%, than don’t need water) 50g NaOH 1ml H2SO4 Firstly, you will make mix with acetic acid and water. Aug 26, 2021 · In pharmaceutical synthesis, P2NP plays a significant role in the production of certain medications such as Adderall. Feb 10, 2024 · I suggest you react p2np with aluminum amalgam. This has been detailed here: J. Molecular Structure and Nitroalkene Functionalities Just talking about how to make phenyl-2-propanone (P2P) also known as phenylacetone…. Talking about the henry reaction in part 1. Its synthesis, properties, and applications have garnered Aug 27, 2021 · Reagents: 1-Phenyl-2-nitropropene (P2NP; cas 705-60-2) 1000 g; Methanol (MeOH) 10 L; Sodium borohydride (NaBH4) 470 g; Hydrogen peroxide (H2O2) 30% 6 L Nov 14, 2019 · Just talking step by step how i would make phenylpropanone more commoly known as phenylacetone or P2P. Aug 15, 2021 · I tried this synthesis on a small scale. Lett. Link to my patreon http Feb 20, 2022 · For small batch reduction of P2NP, this method is faster and safer than using aluminum foil and mercury salts, and there are no toxic mercury salts in the reaction,and the yield of this reaction is relatively high 1-phenyl-2-nitropropene - 5 g (0. Phys. We take 14 g of aluminum foil and tear it with our hands into pieces Apr 4, 2023 · The full synthesis video is available on the official website:https://bbgate. 4. Chem. 2. Buy BMK Oil, Powder Online There are many online stores on the Internet to claim they offer 99. P2NP serves as an intermediate compound in the synthesis of amphetamines, including Adderall. Coupling of Benzyl Chloride and Acetyl Chloride, Semipinacol Rearrangement of Phenyl-2-Propanal, Acetone Enolate add'n to Bromobenzene, Mn +3-mediated radical Oct 17, 2024 · To achieve the desired synthesis results, it is necessary to purify the initial P2P from impurities. I then stopped the synthesis, quenched the reaction with H2o and put it in a canister. Apr 9, 2024 · Exploring the Chemistry: Behind the Scenes of P2NP Synthesis. The only interesting thing about ready-made amphetamines is that I just don't feel the huge euphoria that I should feel, it's not Im using a varient to form the substituted p2np, thinking yields could be better and fuck LAH the acidic al/hg I get decent yields with, but not as good as the borohydride example mentioned in this thread on p2np :o Ill have a go with borohydride if its feasible n no ones tried In the course of the authors' educational program in pharmacochemsitry, literature research was performed on the synthesis of amphetamine and pervitin. I already made two Batches withe the same result: a much to high yield of whatever anorganic salts (for example 85g from 10g of P2NP). Jun 9, 2018 · Distill your benzaldehyde then try using the ammonium acetate in acetic acid conditions. . Feb 16, 2024 · Introduction: P2NP, or phenyl-2-nitropropene, is a chemical compound with significant importance in organic synthesis and industrial applications. If will be 70%, than you Aug 11, 2021 · The bucket with mixture is put into a freezer for 12 hours, 1-phenyl-2-nitropropene (P2NP) is crystallized. The Minnesota 2006 exchange correlation functional M06-2X in conjugation with aug-cc-pVTZ basis set and SMD universal solvation model have been used to elucidate the kinetics Scribd is the world's largest social reading and publishing site. so what i was thinking was using methanol and toluene as solvents and using acetic acid with the ammonium acetate as buffer solution. I have a friend who makes amphetamines from P2NP (maybe that's how I refer to nabh4/cuci2). In the lab, phenyl-2-nitropropene is produced by the reaction of benzaldehyde and nitroethane in the presence of a basic catalyst like n-butylamine. Oxidative rearrangement of olefins with thallium(III)nitrate: A simple one-step synthesis of aldehydes and ketones. Aug 11, 2021 · Hi Not sure if this is the right section but does anyone know if this recipe will work? Preparation of phenylnitropropanol: Into a suitable beaker or conical flask place 51mls of benzaldehyde, followed by 33mls of nitroethane, immediately thereafter add in 30 mls of a 30% potassium Apr 4, 2023 · This is gonna yield you pretty pure racemic d and l isomer amphetamine id imagine, I haven't watched the video in a while but I believe its reductive amiantion reducing p2np with NA BH4 USING the anhydride to reduce the nitropene etc etc, if you are still lost maybe a more simple compound would help, the mescaline from styrene helped me Aug 15, 2021 · Luckily this happened shortly before the addition of CuCl2. I did some digging and found this one guy who says this will not work as I have already brought Explore the detailed methods and processes involved in the synthesis of P2NP and understand its relation to the Henry Reaction in organic chemistry. It doesn't take elaborated glassware or exotic reagents, all used techniques are extremely simple. A. " The following variation of the Knoevenagel reaction will give higher yields of product than the first Oct 8, 2018 · Synthesis of primary amines via operationally simple, inexpensive and environmentally friendly methodologies has high impact in industrial settings. com/threads/1-phenyl-2-nitropropene-p2np-video-synthesis-from-benzaldehyde-and-n The full synthesis video is available on the official website:https://bbgate. In our case, a synthesis was chosen, in which simple reagents and rapid synthesis were used, which is maximally adapted to «home conditions». It is commonly recognized that this material acts as a bridge during the synthesis of several other chemicals. ANOTHER METHOD OF P2P SYNTHESIS. 9g in 20ml H2O NaOH 25. I’ll be more specific here. Each of these methods is suitable for specific working conditions. Link to my patreon https Aug 27, 2021 · Hey Patton, sorry for the lack of information. MAYBE . It involves the conversion of benzaldehyde to p2np through a series of steps, including nitration and reduction. 63 g, 10 mmol, powdered iron 3 g, FeCl3 0. Sep 12, 2023 · amazing videos, always love watching (;, but I believe the salting of the methamphetamine HCL the pH has to be higher than 2, 2 is too low and will leave you with an offwhite product if you just “neutralize” the freebase with the HCL gas to a pH of 6-7 that should be addicute, also additionally would love to see a recrystallization of the methamphetamine in the same format of these types Sep 2, 2021 · A solution of 1-phenyl-2-nitropropene 10 g in 100 ml of isopropyl alcohol and 50 ml of acetic acid is prepared before the synthesis start. By: Search Advanced search… Prepar solut ion of 5g P2NP and I PA 5g in t o 50m l of warm I PA t o cool. Adderall is a widely prescribed drug used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. A compilation of the foremost prevalent amphetamine syntheses approaches exists, each possessing its individual pros and cons. Mixture was bubbling a lot, with small and abundant bubbles. my aceticc acid is only 80%. Water we need, because we are I would love to represent you this simple method of Xanax (Alprazolam; Xanor, Niravam; 8-chloro-1-methyl-6-phenyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine) synthesis. e Jul 16, 2023 · Hello, as I already described in another thread I got problems with the synthesis of amphetamine phosphate from P2NP via Al/Hg. 0 Free-Radical alkylation of Benzene with Acetone Catalyzed by Manganese(III)Acetate 17 Phenyl-2-Propanone can be made in a single step by a free-radical reaction between benzene and acetone. The P2NP oil layer will slowly (or sometimes quickly) start forming a crystalline layer. When no yellow crystals of P2NP were visible anymore in the RM, total of ~1,2 ml of CuCl2 solution was added drop-wise using a 1 ml Pasteur pipette. Extract the free base with isopropyl alcohol Feb 5, 2024 · Beyond its role in the clandestine synthesis of amphetamines, P2NP has drawn attention due to its unique chemical structure and potential applications in various research fields. thank you all!! I found two potentially OTC, novel routes to getting either amphetamine or phenethylamine, starting with P2nP or nitrostyrene. Sep 2, 2021 · A solution of 1-phenyl-2-nitropropene 10 g in 100 ml of isopropyl alcohol and 50 ml of acetic acid is prepared before the synthesis start. Aug 15, 2021 · The first time 80g P2NP, the second time 200g P2NP and the last time 250g P2NP. If even this won't help, it means you probably fucked something up. I will give the Al/hg method a go sometime though , just for fun. Link to CHEMPLAYER doin Aug 15, 2021 · Language Joined Mar 27, 2022 Messages 288 Reaction score 168 Points 43 Phenyl-2-Nitropropene: Synthesis, Properties, and Applications Introduction to 1-Phenyl-2-Nitropropene (P2NP) 1-Phenyl-2-Nitropropene (P2NP) is a chemical compound with the molecular formula C 9 H 9 NO 2. from h202 and conc HCL first, until total dissolution, quenched oxidizing agent w. 188/https://bbgate. 200mg copper chloride in 5ml water and add it, but the temperature does not increase. 038 mol of P2NP 68% of the benzaldehyde was made into P2NP there is 4. 6g in 80ml H2O First water and then IPA were filled into the flask Nov 5, 2024 · The synthesis of amphetamine from p2np al/hg is considered quite simple, but it has its own characteristics. They give 300ml HCl to achieve acidity, so in yours method in a big scale, how much HCl will we need? These processes are relatively simple, high yielding and avoid the use of controlled chemicals. zrtofcdyvvnfcuxlihbiqicqdcifhnrtqqozrslfawwqtisiprucw