Methylisothiazolinone uses And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial Methylisothiazolinone (MIT) has been used in combination with methylchloroisothiazolinone (CMIT) for cosmetic products such as shampoo, body lotion, and skin care products. Increases in the allowable concentration of MI alone in these products has led to an epidemic of allergic contact dermatitis (ACD). [4] It is typically used in a formulation with 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT), in a 3:1 mixture (CMIT:MIT) sold commercially as Kathon . 1111/cod. They also mention, “Any product that contains water is particularly susceptible to being spoiled by microbial growth, causing problems such as The uses of Methylisothiazolinone in paints and other non-cosmetic products were described in the original safety assessment. 7, 11 In Canada, use of MCI/MI and MI is prohibited in leave-on products, and use of MI is restricted to a maximum of 15 ppm in rinse Jun 16, 2022 · Methylisothiazolinone(MIT), along with other isothiazolinones, is a biocide widely used as a preservative in personal care products. Methylparaben is often used in food, drugs, and cosmetic products. Isothiazolinones are used in cosmetic and as chemical additives for occupational and industrial usage due to their bacteriostatic and fungiostatic activity. 5 Methylisothiazolinone was reported to be used in noncolor-ing hair sprays and hair tonics or dressings that may be aero- Methylisothiazolinone (MI) is a preservative whose use is on the rise. Nov 15, 2019 · Methylisothiazolinone . May 9, 2019 · Methylchloroisothiazolinone (MCI) is a preservative that’s active against bacteria, yeast, and fungi. Jul 14, 2023 · everytime I use dawn dish soap without gloves my hands become inflamed with a rash. 1 Product Code: 22589 Section 1. Panel Meeting Date: September 8-9, 2014. 01% reported in multiple product categories including eye makeup remover, hair shampoos and conditioners, and skin care products (both leave-on and rinse-off). MI032020rep in the pdf document. 3. In 1992, the original report on MCI/MI was published by the Cosmetic Ingredient Review (CIR), and Methylisothiazolinone is used commonly in products in conjunction with methylchloroisothiazolinone, a mixture sold under the registered trade name Kathon CG. However, as MI use became more prevalent, increasing reports of ACD followed. It can be found under the name METHYLISOTHIAZOLINONE. Uses advised against: none; Company Identification. Methylisothiazolinone can be a hazardous ingredient when used in high concentrations as it causes severe allergies and skin sensitization. Jan 6, 2025 · Uses. Use Profile Methylisothiazolinone is used to and algae in pulp/paper mills, cooling industrial process waters, and air adhesives, coatings, fuels, metal various other speciality industrial control the growth of mold, mildew, Formulations include soluble concentrated solids. 3 According to information from the Food and Drug Administration (FDA) Voluntary Cosmetic Registration Program (VCRP) database in 2007, MI had 1,125 reported uses, with the majority of the uses reported in noncoloring hair conditioners and shampoos. In 2013, the Expert Panel re-evaluated new data on these two ingredients. Contact Dermat. Although it might seem likely that testing with methylchloroisothiazolin … Sep 25, 2020 · Methylisothiazolinone DrugBank Accession Number DB15884 Background. United States Environmental Protection Agency Prevention, Pesticides And Toxic Substances (7508C) EPA-738-F-98-008 October 1998 R. 2-Methyl-4-isothiazolin-3-one. , F. ” Jun 11, 2024 · Methylisothiazolinone (MI) is an effective preservative widely used in numerous personal care products, industrial products, and even in some household cleaners. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Methylisothiazolinone Company Name: Cayman Chemical Company 1180 E. Despite their effectiveness as biocides, isothiazolinones are strong sensitizers, producing skin irritations and Jan 25, 2022 · The Canadian government has actually banned it for use in leave-on cosmetics but it is still allowed in rinse-off products at the maximum allowed concentration of 0. 7 Feb 25, 2020 · This safety assessment is on the combination of Methylchloroisothiazolinone (MCI) and Methylisothiazolinone (MI) as used in cosmetics. 27 to 23.  Int J Toxicol . Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics Status: Draft Amended Report for Panel Review Release Date: February 21, 2014 Panel Meeting Date: March 17-18, 2014 The 2014 Cosmetic Ingredient Review Expert Panel members are: Chairman, Wilma F. Feb 23, 2020 · Methylisothiazolinone is commonly used in wastewater treatment processes [4], cosmetics, paints, and detergents [5], and in combination with MCI (in proportions of 3:1) as an active ingredient. The increasing use has also been used fueled by the industry’s reaction to the consumers’ anti-parabenes frenzy which gained strength in the second half of the 00’s. A mixture of 3:1 chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) under the brand name Kathon CG has been extensively used in water-based industrial products and cosmetic applications as a preservative. Annex V of the EU Cosmetics Regulation makes it clear that the use of CMIT/MIT is incompatible with the use of MIT alone in the same product. The results show that Kathon, a widely used biocide against microorganisms, and its two constituents, chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT), can cause considerable levels of mortality to whiteflies and aphids when applied at concentrations close to, or lower than, the upper limit of these chemicals permitted in maximum concentration of use range of 3. Sensitization to this family of preservatives was observed as early as the late 1980s. The uses have increased significantly since the original report on MCI/MI was published: in 1986, the total number of uses reported for the ingredient mixture was 381. To identify it in our products, take a look at the ingredients list on packaging. It must be used in MI was initially used occupationally, in paints, adhesives/glues and cleaners etc, as a mixture with methylchloroisothiazolinone (MCI). S. Search DermNet Ctrl K methylisothiazolinone the complete directions for use for each use pattern: site of application, type of application, timing of application, equipment used for application, and the rate of application (dosage). Easy-to-use, formaldehyde-free, and highly stable, Methylisothiazolinone remains functional at up to 70°C, providing potent antimicrobial protection and versatility for many personal care products. As a Benzisothiazolinone supplier, we use it in several of our products as a biodegradable preservative that is a better alternative to formaldehyde, methylisothiazolinone, and medium-chain triglycerides. The use of Methylisothiazolinone (MI) is a related allergen which may show immunologic cross-reactions to octylisothiazolinone. [3] Subject: Draft Amended Report on the Safety Assessment on Methylisothiazolinone . Use Profile Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, I Benzisothiazolinone (BIT) is an organic compound widely used as an industrial preservative for its antimicrobial properties. Table 5. The other procedures used for the dermal application study were similar to those in . Choulis, in Side Effects of Drugs Annual, 2014 Methyisothiazolinone. Maria Antonieta Rios Scherrer và cộng sự (Ngày đăng: năm 2015). The preservative methylisothiazolinone (MI) is the American Contact Dermatitis Society Contact Allergen of the Year for 2013. Enclosed is the Draft Final Amended Report of the Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone (MCI/MI) as Used in Cosmetics. Methylisothiazolinone contact allergy: a review. euxyl K 100 distributed by DKSH (produced by Schülke and Mayr) is a liquid cosmetic preservative. It is also used in glue production, detergents, paints, fuels, and other industrial processes. MIT is a colorless, clear liquid with a Oct 2, 2023 · The biggest concern with this ingredient came to light when researchers conducted two recent laboratory studies on rat brain cells, and found that MIT caused damage to those cells. Type Small Molecule Groups Experimental Structure. 5 10 8%to 0. Skin Two cases of airborne allergic contact dermatitis caused by the preservative methylisothiazolinone in paint have been reported [83 A], and contact allergy to methylisothiazolinone has been reviewed [84 R]. But, it turns out that the molecule is extremely allergenic, it's nerd! Aug 25, 2023 · - UV absorber: Methylisothiazolinone can be used as a UV absorber in products such as sunscreens, sunscreen lotions and sunscreen sprays to protect the skin from UV radiation. It has been used as a substitute for parabens in so-called "paraben free" products by a number of brands. While their preservative efficacy remains undisputed, their effects on the human body following their use on leave-on cosmetic products cannot deemed safe due to a rising trend in allergic reactions Description: methylisothiazolinone is the heterocyclic organic compound CAS #: 2682-20-4 and the permitted use level is very low (under 0. 01% in cosmetics. H. This preservative is commonly found in skin and hair care products, especially wipes. This study evaluated the use of MI in products specifically marketed for babies and children and examined the associated marketing terms of such products. In 1992, the original report on MCI/MI was published by the Expert Panel for Cosmetic Ingredient Safety It also has wide industrial uses. - Wood preservatives: Due to their excellent fungicidal properties, methylisothiazolinone is used as a wood preservative to protect wood from fungus, mold and decay. It’s also Methylisothiazolinone is used for controlling microbial growth in water-containing solutions. Preparation method and application of methylisothiazolinone Apr 22, 2022. Sep 22, 2022 · It dissolves in water and is used in water-based solutions, such as pastes, paints, and oils. 01%. Company: Chemicalbook CMIT/MIT, a mixture of Chloromethylisothiazolinone (CMIT) and Methylisothiazolinone (MIT), is a widely used antimicrobial agent. Methylisothiazolinone (MI) is a preservative commonly used in water-based personal care products. This chemical substance is primarily included in formulations to prevent the growth of bacteria, yeast, and fungi, ensuring the products remain safe and effective for use over time. May 18, 2017 · ThinkBaby and ThinkSport sun care products. A. MI had been shown to be a less potent sensitizer, while still able to protect products from microbial contamination. Allergic contact dermatitis reported in workers using products containing this preservative; [Kanerva, p. Contact dermatitis to methylisothiazolinone, PubMed. They can be found in shampoo, conditioner, body wash, lotion, mascara, shaving cream, baby lotion, hairspray, makeup remover, household cleaner, and a variety of other products. In 2019, the Amended Safety Assessment of Methylisothiazolinone. In April 2020, the US Oct 31, 2023 · Methylisothiazolinone (MI or MIT) is a skin sensitizing, organic compound used as a preservative in personal care products, including skin care and hair care products, although it originated as a preservative for industrial and household applications. 01%, with 0. Where is methylisothiazolinone found? This substance is a preservative used in personal hygiene products (such as shampoos, lotions, emulsions, and sun screens), and in industrial cooling oils, cutting oils, and paper finishes. Mar 15, 2019 · The higher concentrations made methylisothiazolinone more attractive to use in a wider range of products and thus the use of the preservative has boomed in the past 10 years. Mar 7, 2015 · The preservative methylisothiazolinone (MI) is the American Contact Dermatitis Society Contact Allergen of the Year for 2013. M D Lundov, T Krongaard, T L Menné & J D ohansen. Testing should also include methylisothiazolinone (MI), a related allergen that has caused an epidemic of contact allergic dermatitis in people using moist wipes and other products containing MI. Common concerns Nov 28, 2016 · Methylisothiazolinone, along with other isothiazolinones, is a biocide widely used as a preservative in personal care products. It is also commonly added to household cleaners as a substitute for formaldehyde. 5 ppm) and in bath oils, tables and salts at up to 0. FACTS Pesticide Reregistration Methylisothiazolinone All pesticides sold or distributed in the United States must be registered by EPA, based on scientific studies showing that they can be used without posing unreasonable risks to people or the environment. 1 Currently, various types of products are registered for its incorporation, including adhesives, coatings, fuels Mar 5, 2020 · Chloromethylisothiazolinone (CMIT) and methylisothiazolinone (MIT) are chemicals that have been widely used in biocides, paints, and cosmetics such as shampoo, body lotions and skin care products safety, cosmetics, methylchloroisothiazolinone, methylisothiazolinone Introduction This safety assessment is on the combination of Methylchlor-oisothiazolinone (MCI) and Methylisothiazolinone (MI) as used in cosmetics. (It is identified as mcimi122019rep in the pdf document. Release Date: June 20, 2014 . Risks associated with methylisothiazolinone Nov 6, 2019 · Isothiazolinones have been used since the 1970s and are preservatives that possess bacteriostatic and fungiostatic activity. E. 002–0. According to the results of this risk assessment, the CMIT/MIT regulatory values currently used in cosmetics are evaluated as appropriate. MCI/MI is an effective antimicrobial at low concentrations. Even in lower concentrations, patch testing is necessary to ensure safe usage. 2-Methyl-4-Isothiazolin-3-one is frequently used in personal care products. to be widely used in Australia as biocidal preservatives in cosmetics, personal care products, baby wipes, cleaning and laundry products (NICNAS, 2018b). Not for medicinal, household or other use. 4% acetic acid with the ratio 1:1:8, respectively, was used. maximum concentration of use range of 3. 4. ) This ingredient combination functions as a preservative in cosmetics. 1272/2008 1. 01b Bath products The uses of Methylisothiazolinone in paints and other non-cosmetic products were described in the original safety assessment. 0090%. In this article, we will review contact dermatitis to the most commonly used isothiazolinones, including trends in rates of allergy globally based on legislative changes, as well as looking at clinical presentation, diagnostic, and future In addition, used patches were collected to analyze the amount of BIT remaining in the patches. The Scientific Committee on Consumer Safety considers the ingredient safe when used as a preservative up to 0. 2021;40(1_suppl)(suppl):20S-33S. MOL SDF 3D-SDF Sep 29, 2020 · Methylisothiazolinone may be used in products that can come into contact with the eyes or mucous membranes; for example, it is reported to be used in bath soaps and detergents at up to 0. Methylisothiazolinone has recently been identified as a neurotoxin that can damage nerve endings with repeated exposure. Objectives: To show sensitization to OIT from leather, and to highlight the potential implications when cross-reactivity between OIT and methylisothiazolinone (MI) is studied. Methylisothiazolinone is typically used in conjunction with methylchloroisothiazolinone. Methylisothiazolinone may be listed as other names on product labels including: Methylisothiazolinone. Dec 20, 2019 · Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0. Chemical structures of isothiazole and of the most frequently used isothiazolinone biocides in consumer products. 2. Nov 9, 2022 · Methylisothiazolinone (MIT) and chloroxylenol (PCMX) are popular disinfectants often used in personal care products (PCPs). The mixture of CMIT/MIT has been found to cause allergic contact dermatitis Widespread Use in Paints and Coatings: BIT is commonly employed in paints, either alone or mixed with methylisothiazolinone. The Agency has determined that methylisothiazolinone products, labeled and used as specified in this Document, will not pose unreasonable risks or adverse effects to humans or the environment. 0090% (90 ppm). Uses: a medicated shampoo with antimicrobial and antifungal activity designed for dogs, cats and horses with dermatological conditions responsive to May 3, 2023 · Purpose of Review Allergic contact dermatitis due to isothiazolinone derivatives is frequently observed both in consumers and in occupational exposures. In 2019, the Mar 16, 2023 · [1] [7] Two of the most commonly used ingredients of this class are methylisothiazolinone (MI) and methylchloroisothiazolinone (MCI), often in combination at a 3:1 ratio and referred to as methylisothiazolinone / methylchloroisothiazolinone (MCI/MI). Detailed assessments of available safety data for Methylisothiazolinone, both alone and when in combination with Methylchloroisothiazolinone, can be found in the following U. Methylisothiazolinone may be used in products that can come into contact with the eyes or mucous membranes; for example, it is reported to be used in bath soaps and detergents at up to 0. 7 The Cosmetic Ingredient Review Expert Panel (Panel) reviewed the safety of methylisothiazolinone (MI), which functions as a preservative. Status: Tentative Report for Public Comment . Jul 14, 2021 · Methylisothiazolinone is reported to function in cosmetics as a preservative, according to the web-based International Cosmetic Ingredient Dictionary and Handbook (wINCI; Dictionary). 0015% or less and is prohibited from use in other cosmetics products. 01%). Methylisothiazolinone and benzisothiazolinone are widely used in paint: a multicentre study of paints from five European countries. 0015%. Oct 29, 2019 · The validated method was used to determine the concentration of isothiazolinones in four commercial water-based adhesives used for food contact materials. Cosmetic Ingredient Review Expert Panel reports: Oct 8, 2014 · INTRODUCTION In 2010, the Panel published a final report of the safety assessment of methylisothiazolinone (MI) with the conclusion that “MI is safe for use in cosmetic formulations at concentrations up to 100 ppm (0. 1 It should be noted safety, cosmetics, methylchloroisothiazolinone, methylisothiazolinone Introduction This safety assessment is on the combination of Methylchlor-oisothiazolinone (MCI) and Methylisothiazolinone (MI) as used in cosmetics. May 8, 2018 · Methylisothiazolinone (MIT) is a particularly effective biocide, which is often used on its own or in a 1:3 ratio with Methylchloroisothiazolinone. Methylisothiazolinone// Methylisothiazolinone DMF, CEP, Written Confirmations, FDF, Prices, Patents, Patents & Exclusivities, Dossier, Manufacturer, Licensing M D Lundov, T Krongaard, T L Menné & J D ohansen. I also use white vinegar (the gallon jug you can find at the grocery store), about 1/3-1/2 cup in the fabric softener slot of my washing machine, in with m The Agency has determined that methylisothiazolinone products, labeled and used as specified in this Document, will not pose unreasonable risks or adverse effects to humans or the environment. MIT and CMIT has reported uses in consumer and industrial sealants and in marine and automotive aftermarket products such as waxes, polishes and coatings. It can also be found in adhesives, plasters, paints. Not Available. Unfortunately regulation of household cleaners is weak in North America so similar guidelines for Methylisothiazolinone use in cleaning products do not exist. Meyers Clean Day’s PR company sent me bottles of all of their dishwashing liquids, hoping to have it reviewed on this site. Mar 15, 2019 · According to 2019 VCRP data, MCI and MI are surveyed separately and not as a mixture. It is found within many commercially available cosmetics, lotions, and makeup removers. It is a part of the preparation of methylchloroisothiazolinone (MCI)/MI, which is patch These substances are used in paint, adhesives, jointing compounds, cutting fluids and detergents. Relevant identified uses: For R&D use only. Hexane and water were used separately as well (50% and 80%). The British journal of dermatology 165(6), 1178-82. Download . Methylchloroisothiazolinone and methylisothiazolinone (MCI/MI), also known as Kathon CG or Euxyl K 100, has been used (in a fixed 3:1 mixture) as a preservative since the 70s. More opportunities for exposure mean more opportunities for contact allergy to this preservative, which is categorized as a moderate-strong sensitizer. The unregulated discharge of these micropollutants into the environment Water, Lauramine Oxide, Polyacrylate-1 Crosspolymer, Cocamidopropyl Betaine, Decyl Glucoside, Glycolic Acid, Fragrance, Tetrasodium EDTA, Methylchloroisothiazolinone, Methylisothiazolinone. All interested persons are provided 60 days from the above release date to comment on this safety assessment and to Subject: Draft Amended Report on the Safety Assessment on Methylisothiazolinone . Methylisothiazolinone or MIT, sometimes erroneously called methylisothiazoline, is a powerful biocide and preservative within the group of isothiazolinones, used in shampoos and body care products. MI has been found to cause high rates of contact allergic dermatitis and was declared the Contact Allergen of the year for 2013 by the American Contact Dermatitis Society. Methylisothiazolinone (MI) is a common preservative used in the personal care industry, however there are now concerns it may trigger allergies in some people. ” Background: Octylisothiazolinone (OIT) is used as an antifungal agent by the leather industry. The blood samples were immediately centrifuged at 18,000× g for 5 min, and the plasma samples (50 μL) were stored at −80 °C until LC–MS/MS analysis. 5 mg/kg, while OIT and DCOIT were not detectable in Methylisothiazolinone SAFETY DATA SHEET Supersedes Revision: 09/23/2017 according to Regulation (EC) No. (It is identified as . A review article reports that this substance is a skin sensitizer. The noticeable biological effects observed for isothiazole-containing compounds have generated an enormous interest on this scaffold for drug discovery and development programs, which resulted in a steady increase in the number of related patent applications as well as in the Rising rates of allergy have been noted due to the preservative methylisothiazolinone (MI). Namely Methylisothiazolinone, better known by the acronym MIT, is used as a synthetic preservative in cosmetics. The researchers stated, “a brief exposure to methylisothiazolinone, a widely used industrial and household biocide, is highly toxic to cultured neurons…. Enclosed is the draft amended report of the safety assessment of Methylisothiazolinone (MI) as used in cosmetics. Methylisothiazolinone is used in cosmetic rinse-off products up to a concentration of 15 ppm as preservative. Is Methylisothiazolinone banned in Europe? Methylisothiazolinone agent detailed information in Haz-Map database. Isothiazolinone mix is more commonly known as the preservative product with the commercial name Kathon. I now use castile soap and rinse in hot vinegar water. Other names include Kathon, Euxyl K 100 and Grotan K. Four isothiazolinones (MI, CMI, BIT and MBIT) were detected with concentration ranging from 2. C. Methylisothiazolinone (MIT) and Methylchloroisothiazolinone (CMIT) are widely used preservatives found in liquid cosmetic and personal care products. This article describes a background overview and preparation and use of Methylisothiazolinone When used alone, Methylisothiazolinone may be used at concentrations up to 0. Parabens are chemicals that are often used as preservatives to give products a longer shelf life. [Google Scholar] 15. . 1177/10915818211016382 PubMed Google Scholar Crossref Oct 30, 2024 · Methylparaben is a type of paraben. In 1992, the original report on MCI/MI was published by the Expert Panel for Cosmetic Ingredient Safety. I use Tide PurClean Unscented, which is wonderful (also a pretty environmentally friendly product compared to most laundry detergents!). Methylisothiazolinone (CMIT/MIT) in 3/1 ratio is approved as a preservative blend for rinse-off cosmetic products at the maximum concentration of 15 ppm in the EU. as Used in Cosmetics . ; Methylisothiazolinone (MI) is a widely used preservative and biocide. Tout savoir sur l'ingrédient cosmétique METHYLISOTHIAZOLINONE (Methylisothiazolinone), n° CAS 2682-20-4, familles (Règlementé, Conservateur), fonction (Conservateur). MI (CAS 2682-20-4) is a powerful biocide and preservative which has been used in Feb 23, 2020 · The importance of isothiazole and of compounds containing the isothiazole nucleus has been growing over the last few years. Although personal care products are the most common source of MI conta … The data suggested that Methylisothiazolinone when used by itself if safe up to 100ppm. Though long considered safe for use in cosmetics, two recent in vitro studies have shown that MIT is neurotoxic, causing damage to rat brain cells Feb 24, 2020 · Why is Methylisothiazolinone used in cosmetic and personal care products? According to cosmeticsinfo. 12322. 1. 3(2H)-Isothiazolone, 2-methyl-2-Methyl-2H-isothiazol-3-one. The Panel reviewed relevant animal and human data provided in this safety assessment and in a previously published safety assessment of MI and concluded that MI i … We use preservatives to keep home and personal care products in good condition: without them, they could be spoiled by bacteria, yeasts and moulds. Vanicream (US) High-tolerance skincare products for those with sensitive skin — free from not only the isothiazolinone preservatives, but fragrances, dyes / colors, parabens and other preservatives. It is often paired with another preservative called methylisothiazolinone under the trade name Kathon CG. What is methylisothiazolinone? Methylisothiazolinone (2-Methyl-4-isothiazolin-3-one) is a preservative. There is limited information regarding isothiazolinone content in residential wall paints in the United States. thanks for all your research Benzyl Alcohol (and) Methylchloroisothiazolinone (and) Methylisothiazolinone. How can I avoid it? Avoidance requires reading the product labels, package inserts, Material Safety Data Sheets (MSDS), and on occasion, direct communication with the manufacturer. 3-10 In North America, positivity to MI and MCI/MI remains high and positivity to BIT continues to rise. 5 Methylisothiazolinone was reported to be used in noncolor-ing hair sprays and hair tonics or dressings that may be aero- May 6, 2023 · It’s also used in some industrial processes for making paints, cutting oils, and glue. Schwensen JF, et al. May 21, 2023 · Methylchloroisothiazolinone is a preservative in many skin care products that stops fungi, yeast, and bacteria from growing. Uses Aug 1, 2021 · During the last decade, the use of methylisothiazolinone (MI) at higher concentrations in both leave-on and rinse-off products has significantly increased. What are some products that contain methylisothiazolinone? These two active ingredients occur together in the currently registered products in approximately a 3:1 ratio, respectively, and 3 ^ are commonly referred to as methylisothiazolinone. It’s used in the manufacture of water-based cosmetics and personal care products. ) This ingredient functions as a preservative in cosmetics. Ellsworth Rd. Because the use of MI in cosmetics and toiletries in the United States rises, MI exposure also rises. The total number of uses reported for MCI are 5137; 480 of these are in leave-on products. This guide provides detailed insights into the chemical properties, applications, and safety considerations of this biocidal mixture, essential for professionals across various industries. some. of products in each category) Ingredient Uses in Each Product Categorya (FDA)9 Use Concentrations, %10 Baby products Shampoos (38) 5— Lotions, oils, powders, and creams (67) 2 — Other (64) 7 0. org, Methylisothiazolinone (MIT) is often used as a mixture with Methylchloroisothiazolinone (MCI). It is a contact allergen and sensitiser. D. It is also sometimes used for industrial purposes in painting, manufacturing, metalworking, mining, and sanitizing. Jul 14, 2021 · This safety assessment is on the combination of Methylchloroisothiazolinone (MCI) and Methylisothiazolinone (MI) as used in cosmetics. N. Uses: This chemical functions as a biocide and preservative within the group of isothiazolinones and is widely used in cosmetics, shampoos, soaps and body care products, cooling fluids, etc. Synonyms: 2-Methyl-4-isothiazolin-3-one; 2-Methyl-3(2H)-isothiazolone. Methylchloroisothiazolinone may appear on labels written like this: Kathon CG 5243; methylchloro-isothiazolinone; methylchloroisothiazolinone Sep 30, 2019 · of uses reported for MCI is 5137; 480 of these are in leave-on products (Table 1). Information on safe use. 3D. Abstract Background. Methylchloroisothiazolinone is known by the registered tradename Kathon CG when used in combination with methylisothiazolinone. Oct 15, 2021 · Methylisothiazolinone (abbreviated as MI or MIT) is a chemical preservatives used in many cleaning products - even the so called green cleaners. The aim of this study was to evaluate the prevalence of 5 isothiazolinones—methylisothiazolinone (MI), methylchloroisothiazolinone, benzisothiazolinone (BIT), butyl BIT, and octylisothiazolinone—in US residential wall paints. What is METHYLISOTHIAZOLINONE and where is it found? This chemical functions as a biocide and preservative within the group of isothiazolinones and is widely used in cosmetics, shampoos, soaps and body care products, cooling fluids, etc. 00755% and in bath oils, tables and salts at up to 0. 1815] Danger of skin sensitization; [MAK] Cosmetic preservative that is a recognized contact allergen in consumers; [EC: SCCS - Opinion] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract Uses: Methylisothiazolinone is an antimicrobial used to control slime-forming bacteria, fungi, and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems, and other industrial settings. when looking further into it found out under fragrance they hide the fact that it contains formaldehyde. 1 Jul 3, 2018 · Methylchloroisothiazolinone (MCI) is an isothiazolinone commonly used as a preservative with antibacterial and antifungal properties. The European Scientific Committee for Consumer Safety (SCCS) assessed the use of methylisothiazolinone in rinse-off products in its opinion of December 2015 on the basis of extensive scientific data as safe. The Council is currently conducting a concentration of use survey. INTRODUCTION In 2010, the Panel published a final report of the safety assessment of methylisothiazolinone (MI) with the conclusion that “MI is safe for use in cosmetic formulations at concentrations up to 100 ppm (0. ” Feb 7, 2021 · What is Methylisothiazolinone used in? Methylisothiazolinone, along with other isothiazolinones, is a biocide widely used as a preservative in personal care products. 1 In 2019, the Expert Panel for Cosmetic Ingredient Safety (Panel) published an amended safety assessment of Methylisothiazolinone with the conclusion that “Methylisothiazolinone is safe for use in rinse-off Methylisothiazolinone is a widely-used preservative; has been associated with allergic reactions. What Is Benzisothiazolinone Made of? Yes. It is also used in many industrial processes, such as paint and paper manufacturing, metalworking, mining, and sanitizing. A mixture of methanol, acetonitrile, and 0. 2011. Methylisothiazolinone is a 1,2-thazole that is 4-isothiazolin-3-one bearing a methyl group on the nitrogen atom. Acetonitrile was also used in different ratios; 50% and 80%. Mrs. In case of any adverse reactions, discontinue use and contact a dermatologist. 1907/2006 as amended by (EC) No. Therefore, the Agency concludes that products containing methylisothiazolinone for all uses are eligible for reregistration. In 1992, the original report on MCI/MI was published by the Expert Panel for Cosmetic Ingredient Safety (Panel) and concluded that this mixture may be “safely used in rinse-off products at a concentration not to exceed 15 ppm and in leave-on cosmetic products Feb 21, 2014 · Amended Safety Assessment of Methylisothiazolinone as Used in Cosmetics Status: Draft Amended Report for Panel Review Release Date: February 21, 2014 Panel Meeting Date: March 17-18, 2014 The 2014 Cosmetic Ingredient Review Expert Panel members are: Chairman, Wilma F. Truy cập ngày 22 tháng 9 năm 2023. MIT is an SVOC (semi volatile organic compound) which can be unsafe for skin and can can cause chemical burns and dermatitis, and irritate skin and membranes. Method dish soap uses synthetic fragrance and color (this one is free of phthalates), and also contains synthetic preservatives and methylisothiazolinone. MI062020rep in the pdf document. MI has 6037 reported uses; 1042 of these are in leave-on products. 2,3 There is the potential for residential and occupational expo-sure when Methylisothiazolinone is used to preserve materials such as paints, cleaners, and plastics. May 18, 2023 · Methylisothiazolinone is a common preservative used in house cleaning supplies and personal care products, including makeup, lotions, shampoos, conditioners, dish soaps, laundry detergents, and more. In 2019, the Methanol was used in different ratios with water; 50% and 80%. Many people are allergic to it or can become so. This new data suggested that Methylisothiazolinone was more allergic to leave-on products than previously understood. doi: 10. Objective. In 2000, MI started being commercialized alone for use in industrial products such as paints and adhesives, and since 2005 it has also been used in cosmetic products at Methylisothiazolinone or MIT is a preservative used in many consumer goods including cosmetic products, to preserve product quality and ensure consumer safety by preventing the growth of microbes. Methylisothiazolinone (MIT) has been used: in research on the effects of the N-methyl D-aspartate (NMDA) receptor antagonist kynurenic acid on human cortical development ; as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death Jan 11, 2025 · Synonyms: Methylisothiazolinone,2-Methyl-4-isothiazolin-3-one; Relevant identified uses of the substance or mixture and uses advised against. 00755% (75. 2-Methyl-3(2H)-isothiazolone. [3] [4] Both chemicals inhibit bacterial growth in cosmetic products on their own, but they are most commonly used as a mixture in products. P. Current Cosmetic Product Uses and Concentrations for Methylisothiazolinone Product Category (total no. May 1, 2019 · Methylisothiazolinone (MI) is used as a preservative in occupational and household products, and cosmetics. It has a broad, balanced spectrum of effect against bacteria, yeasts and mold fungi. Amended safety assessment of methylchloroisothiazolinone and methylisothiazolinone as used in cosmetics. In April 2020, the US Aug 2, 2023 · We use benzisothiazolinone in several of our products as a biodegradable preservative that is a better alternative to formaldehyde, methylisothiazolinone, and medium-chain triglycerides. A common indication of sensitivity to Kathon CG is allergic contact dermatitis. O MIT é alérgeno e citotóxico, e isso levou a alguma preocupação com seu uso. Aug 25, 2023 · Methylisothiazolinone (MIT) เป็นสารกันบูดและยาฆ่าเชื้อราที่ใช้กันทั่วไปซึ่งมีการใช้งานที่หลากหลาย. 01% (100 ppm). 1,2 Methylisothiazolinone was approved for use as a preservative in cosmetics in 2005 at a maximum concentration of 100 ppm Dec 9, 2016 · Methylisothiazolinone (MI) and Methylchloroisothiazolinone (MCI) are preservatives commonly used in cosmetics and personal care products to prevent microbial growth. The widespread use of isothiazolinones led to a world-wide epidemic of allergic contact dermatitis (ACD). As mentioned, MIT is a preservative used in haircare products like shampoos and conditioners. Since 2005, it has been widely used in cosmetics and household products, such as moist wipes, shampoos, cleaners and liquid laundry products. Paint, adhesive and detergents are products sold for both professional and consumer use. The brand told us that “methylisothiazolinone is not an ingredient used in any Think products”. Methylisothiazolinone is a preservative compound widely used in cosmetics. A worldwide yearly survey of new data in adverse drug reactions and interactions. (2) Use on Pilings Methylisothiazolinone is to be used only on terrestrial-use pilings not aquatic-use pilings. Because MIT can cause allergic reactions in a small percentage of the population, Yadav suggests being mindful of the amount of the ingredient is in the product, especially if you have any skin conditions. Jun 30, 2010 · Methylisothiazolinone (MIT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0. Jul 15, 2015 · The European Commission’s SCCS has published its opinion on the safety-in-use of MI in cosmetic products. Methylchloroisothiazolinone was first used in cosmetics in the 1970s. In How to tell if a product has methylisothiazolinone. Unfortunately, it is a known allergen with many confirmed contact dermatitis and sensitization cases. Bergfeld, M. The extensive use of a mixture of isothiazolinones (methylchloroisothiazolinone in fixed 3:1 combination with methylisothiazolinone; MCI/MI; Kathon™ CG) in cosmetic products resulted in the 1980s in a rapid increase of new cases of contact allergy to this mixture. Jun 27, 2022 · How to Use Methylisothiazolinone for Hair . This is the first North American Contact Sep 22, 2023 · Amended Safety Assessment of Methylchloroisothiazolinone and Methylisothiazolinone as Used in Cosmetics, PubMed. Jun 6, 2019 · Methylisothiazolinone functions as a preservative in cosmetic products. [8] [9] Um relatório divulgado pelo Comitê Científico Europeu de Produtos Cosméticos e Produtos Não Alimentícios Destinados aos Consumidores (SCCNFP) em 2003 também concluiu que informações insuficientes estavam disponíveis para permitir uma análise de avaliação de risco adequada do MIT. 2015;72:127–138. Methylisothiazolinone is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. normally I wear gloves but got holes in the last ones. 01%) and safe in leave-on cosmetic products when Chemicals like methylchloroisothiazolinone and methylisothiazolinone have been used in a plant tissue culture medium and have proved to be nonphytotoxic and used to kill the bacterial and fungal contaminations (Niedz, 1998). Current regulations indicate that CMIT/MIT can only be used at concentrations 0. The Panel reviewed relevant animal and human data provided in this safety assessment, and data from the previously published safety assessments of Methylisothiazolinone, and concluded that Methylisothiazolinone is safe for use in rinse-off cosmetic products at concentrations up to 100 ppm (ie, 0. 7 Feb 21, 2020 · Subject: Draft Amended Report on the Safety Assessment on Methylisothiazolinone . The results are shown in Table 3. ; Your patch tests indicate that you have a contact allergy to methylisothiazolinone. Burnett CL, Bergfeld WF, Belsito DV, et al. Lab studies on the brain cells of mammals also suggest that methylisothiazolinone may be neurotoxic. Jun 22, 2018 · In the early 2000s, as use of MCI decreased due to sensitization concerns, use of MI increased. Its use has seen a dramatic rise over the years, with a significant presence in house paints, varnishes, and coatings. tqif qyci nlvah qmut ajcir earbi hoiqp dnqnleea wwvvr ettx